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A systematic survey of LU domain-containing proteins reveals a novel human gene, LY6A, which encodes

Frontiers of Medicine 2023, Volume 17, Issue 3,   Pages 458-475 doi: 10.1007/s11684-022-0968-4

Abstract: The Ly-6 and uPAR (LU) domain-containing proteins represent a large family of cell-surface markers.In this study, based on a systematic survey and comparative genomic study of mouse and human LU domain-containingWe cloned the full-length LY6A cDNA, whose encoded protein sequence, domain architecture, andEctopic expression of the LY6A protein in cells demonstrates that it acts the same as mouse Ly-6A/Sca

Keywords： LU domain-containing protein family     novel human gene     LY6A     pituitary tumor     biomarker     nonsynonymousSNP     GPI-anchored protein    

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FERM domain-containing protein FRMD6 activates the mTOR signaling pathway and promotes lung cancer progression

Frontiers of Medicine 2023, Volume 17, Issue 4,   Pages 714-728 doi: 10.1007/s11684-022-0959-5

Abstract: FRMD6, a member of the 4.1 ezrin–radixin–moesin domain-containing protein family, has been reported to

Keywords： FRMD6     lung cancer     mTOR pathway    

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Dual faces of SH2-containing protein-tyrosine phosphatase

Shuangwei Li, Diane DiFang Hsu, Hongyang Wang, Gen-Sheng Feng

Frontiers of Medicine 2012, Volume 6, Issue 3,   Pages 275-279 doi: 10.1007/s11684-012-0216-4

Abstract:

PTPN11, which encodes tyrosine phosphatase Shp2, is a critical gene mediating cellular responses to hormones and cytokines. Against original prediction as tumor suppressor for tyrosine phosphatases, PTPN11 was first identified as a proto-oncogene because activating mutations of this gene are associated with leukemogenesis. However, most recent experimental data suggest PTPN11/Shp2 acting as a tumor suppressor in hepatocarcinogenesis. This review focuses on the tumor-promoting or suppressing roles of the gene PTPN11/Shp2 in different cell types.

Keywords： PTPN11/Shp2     leukemia     hepatocellular carcinoma     mutation    

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Keratin 5-Cre-driven deletion of

Jun Yang, Lianqing Wang, Yingzhi Huang, Keqiang Liu, Chaoxia Lu, Nuo Si, Rongrong Wang, Yaping Liu, Xue

Frontiers of Medicine 2020, Volume 14, Issue 3,   Pages 305-317 doi: 10.1007/s11684-019-0722-8

Abstract: RNA-Seq analysis indicated that Sprr2d, a member of the small proline-rich protein 2 family, in the skin

Keywords： acne inversa mouse model     interleukin 1 family     member 6     small proline rich protein 2D     key inflammatory    

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PROTECTIVE ROLES OF D1 PROTEIN TURNOVER AND THE XANTHOPHYLL CYCLE IN TOMATO (

Tao LU, Jiazhi LU, Mingfang QI, Zhouping SUN, Yufeng LIU, Tianlai LI

Frontiers of Agricultural Science and Engineering   Pages 262-279 doi: 10.15302/J-FASE-2021383

Abstract: D1 protein turnover and the xanthophyll cycle (XC) are important photoprotective mechanisms in plants, streptomycin sulfate (SM) and dithiothreitol (DTT) were used in tomato plants as inhibitors of D1 proteinquenching and decreased chlorophyll pigments in SM and DTT application, causing an inhibition of D1 protein

Keywords： D1 turnover     photoinhibition     photoprotection     photosynthesis     tomato     xanthophyll cycle    

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Numerical study on natural convection in a square enclosure containing a rectangular heated cylinder

Jianhua LU, Zhaoli GUO, Zhenhua CHAI, Baochang SHI,

Frontiers in Energy 2009, Volume 3, Issue 4,   Pages 373-380 doi: 10.1007/s11708-009-0078-x

Abstract: In this paper, the natural convection in a square enclosure with a rectangular heated cylinder is investigated via the lattice Boltzmann method. A detailed study is conducted on the effect of the cylinder width and the Rayleigh number on the fluid flow and heat transfer. The flow structures and heat transfer patterns are classified into eight buoyant regimes, i.e., four steady regimes, two periodic regimes, one multiple periodic regime, and one chaos regime, two of which are reported for the first time.

Keywords： natural convection     buoyant regime     heated cylinder     lattice Boltzmann    

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Investigation of phosphate adsorption from an aqueous solution using spent fluid catalytic cracking catalyst containing

Zhen Li, Zhaofu Qiu, Ji Yang, Benteng Ma, Shuguang Lu, Chuanhui Qin

Frontiers of Environmental Science & Engineering 2018, Volume 12, Issue 6, doi: 10.1007/s11783-018-1082-3

Abstract:

Spent FCC catalyst with lanthanum is proposed as a novel P-removal adsorbent.

The spent FCC catalyst exhibits 99% adsorption efficiency for low P-concentration wastewater (C0 <5.0 mg/L).

High affinity, endothermic reaction and fast sorption kinetics are achieved.

The phosphate is adsorbed in the form of LaPO4 and KH2PO4.

Keywords： Spent FCC catalyst     Phosphate removal     Adsorption     Lanthanum    

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Treatment of soybean wastewater by a wild strain Rhodobacter sphaeroides and to produce protein under

Junguo HE, Guangming ZHANG, Haifeng LU,

Frontiers of Environmental Science & Engineering 2010, Volume 4, Issue 3,   Pages 334-339 doi: 10.1007/s11783-010-0239-5

Abstract: Purple nonsulfur bacteria (PNSB) wastewater treatment is a clean technology and can generate single cell proteinThe Z08 biomass yield was 0.28g·g, and the bacterial protein content was 52%.

Keywords： purple nonsulfur bacteria (PNSB)     Rhodobacter sphaeroides Z08     soybean wastewater     cost effective    

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Development and clinical trial of a novel bioactive bone cement

LEONG John, LI Zhaoyang, LU William

Frontiers of Medicine 2008, Volume 2, Issue 2,   Pages 117-126 doi: 10.1007/s11684-008-0022-1

Abstract: Previously, we developed a novel bioactive bone cement which is mainly composed of strontium-containing

Keywords： bioactivity     effectiveness     strontium-containing hydroxyapatite     osseointegration     sufficient mechanical    

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Moving target detection in the cepstrum domain for passive coherent location (PCL) radar

Ji-chuan LI,Xiao-de LU,Hui ZHANG,Peng-cheng YANG,Yu LIU,Mao-sheng XIANG

Frontiers of Information Technology & Electronic Engineering 2015, Volume 16, Issue 9,   Pages 785-795 doi: 10.1631/FITEE.1500036

Abstract: A cepstrum moving target detection (CEPMTD) algorithm based on cepstrum techniques is proposed for passive coherent location (PCL) radar systems. The primary cepstrum techniques are of great success in recognizing the arrival times of static target echoes. To estimate the Doppler frequencies of moving targets, we divide the radar data into a large number of segments, and reformat these segments into a detection matrix. Applying the cepstrum and the Fourier transform to the fast and slow time dimensions respectively, we can obtain the range information and Doppler information of the moving targets. Based on the CEPMTD outlined above, an improved CEPMTD algorithm is proposed to improve the detection performance. Theoretical analyses show that only the target’s peak can be coherently added. The performance of the improved CEPMTD is initially validated by simulations, and then by experiments. The simulation results show that the detection performance of the improved CEPMTD algorithm is 13.3 dB better than that of the CEPMTD algorithm and 6.4 dB better than that of the classical detection algorithm based on the radar cross ambiguity function (CAF). The experiment results show that the detection performance of the improved CEPMTD algorithm is 1.63 dB better than that of the radar CAF.

Keywords： Moving target detection     Cepstrum techniques     Cross ambiguity function (CAF)     Passive coherent location (PCL) radar    

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Epidemiological study of a von Hippel-Lindau family in northwest China

Jingyao Zhang, Dapeng Wu, Hong Ai, Jigang Bai, Shunbin Dong, Qinling Yang, Kai Qu, Lei Zhou, Xinsen Xu, Chang Liu

Frontiers of Medicine 2013, Volume 7, Issue 3,   Pages 378-385 doi: 10.1007/s11684-013-0276-0

Abstract: We encountered a large VHL family in northwest China and conducted a systematic screening of the familyFor the preliminary family screening, physical examination and abdomen B ultrasonography were performedA total of 63 lineal descendants in six generations were observed in the family (generations O, A, B,Therefore, follow-up checkups of the family should be focused on younger generations.Proper family screening protocols should be followed for the treatment of patients with VHL disease.

Keywords： von Hippel-Lindau disease     epidemiology     family screening     pancreatic endocrine tumor    

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Hepatitis B virus X protein upregulates tumor necrosis factor-α expression of rat mesangial cell

Hong-Zhu LU MD, Dan LIU BM, Qi-Hong FAN BM, Jian-Hua ZHOU MD,

Frontiers of Medicine 2010, Volume 4, Issue 1,   Pages 106-111 doi: 10.1007/s11684-010-0004-y

Abstract: Hepatitis B virus X protein (HBx), a 17-kd protein encoded by X gene of hepatitis B virus (HBV), hasThe aim of the study is to investigate the extracellular regulated protein kinases (ERKs) pathway ofPCI-neo containing HBV X gene (pCI-neo-X) was then transfected into cultured GMC line via liposome.can conclude that HBx could induce GMC proliferation and increase TNF-α mRNA expression and its protein

Keywords： hepatitis B virus     X gene     glomerular mesangial cell line     extracellular regulated protein kinases     tumor    

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The Advanced Gun Family——the birth of type 95 (5.8 mm) squad gun family

Duo Yingxian

Strategic Study of CAE 1999, Volume 1, Issue 2,   Pages 57-61

Abstract: So after a short period of cooperated work, a new advanced squad gun family has been developed basedThis guns family were already used to equip the army assigned to Hong Kong in January, 1997 and shall

Keywords： squad gun family     automatic rifle     machine rifle     assault rifle    

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Time-domain and frequency-domain approaches to identification of bridge flutter derivatives

Zhengqing CHEN

Frontiers of Structural and Civil Engineering 2009, Volume 3, Issue 2,   Pages 173-179 doi: 10.1007/s11709-009-0034-1

Abstract: method and a frequency-domain method.It was shown that all the flutter derivatives of the thin-plate model identified with the frequency-domainmethod and time-domain method, respectively, agree very well.More precisely, the frequency-domain method usually results in smooth curves of the flutter derivativesThe formulation of time-domain method makes the identification results of flutter derivatives relatively

Keywords： long-span bridges     wind-induced vibration     flutter derivatives     forced vibration test     time-domain method     frequency-domain method    

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Identification of novel mutations in and in a family with craniofacial microsomia: evidence of digenic

Frontiers of Medicine   Pages 1006-1009 doi: 10.1007/s11684-023-1000-3

Abstract: Identification of novel mutations in and in a family with craniofacial microsomia: evidence of digenic

Keywords： family craniofacial microsomia     Identification novel mutations    

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Title Author Date Type Operation

A systematic survey of LU domain-containing proteins reveals a novel human gene, LY6A, which encodes

Journal Article

FERM domain-containing protein FRMD6 activates the mTOR signaling pathway and promotes lung cancer progression

Journal Article

Dual faces of SH2-containing protein-tyrosine phosphatase

Shuangwei Li, Diane DiFang Hsu, Hongyang Wang, Gen-Sheng Feng

Journal Article

Keratin 5-Cre-driven deletion of

Jun Yang, Lianqing Wang, Yingzhi Huang, Keqiang Liu, Chaoxia Lu, Nuo Si, Rongrong Wang, Yaping Liu, Xue

Journal Article

PROTECTIVE ROLES OF D1 PROTEIN TURNOVER AND THE XANTHOPHYLL CYCLE IN TOMATO (

Tao LU, Jiazhi LU, Mingfang QI, Zhouping SUN, Yufeng LIU, Tianlai LI

Journal Article

Numerical study on natural convection in a square enclosure containing a rectangular heated cylinder

Jianhua LU, Zhaoli GUO, Zhenhua CHAI, Baochang SHI,

Journal Article

Investigation of phosphate adsorption from an aqueous solution using spent fluid catalytic cracking catalyst containing

Zhen Li, Zhaofu Qiu, Ji Yang, Benteng Ma, Shuguang Lu, Chuanhui Qin

Journal Article

Treatment of soybean wastewater by a wild strain Rhodobacter sphaeroides and to produce protein under

Junguo HE, Guangming ZHANG, Haifeng LU,

Journal Article

Development and clinical trial of a novel bioactive bone cement

LEONG John, LI Zhaoyang, LU William

Journal Article

Moving target detection in the cepstrum domain for passive coherent location (PCL) radar

Ji-chuan LI,Xiao-de LU,Hui ZHANG,Peng-cheng YANG,Yu LIU,Mao-sheng XIANG

Journal Article

Epidemiological study of a von Hippel-Lindau family in northwest China

Jingyao Zhang, Dapeng Wu, Hong Ai, Jigang Bai, Shunbin Dong, Qinling Yang, Kai Qu, Lei Zhou, Xinsen Xu, Chang Liu

Journal Article

Hepatitis B virus X protein upregulates tumor necrosis factor-α expression of rat mesangial cell

Hong-Zhu LU MD, Dan LIU BM, Qi-Hong FAN BM, Jian-Hua ZHOU MD,

Journal Article

The Advanced Gun Family——the birth of type 95 (5.8 mm) squad gun family

Duo Yingxian

Journal Article

Time-domain and frequency-domain approaches to identification of bridge flutter derivatives

Zhengqing CHEN

Journal Article

Identification of novel mutations in and in a family with craniofacial microsomia: evidence of digenic

Journal Article